This section contains information and studies on the impacts of rotenone to public health.<\/p>\n
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Betarbet, R., T. Sherer, G. MacKenzie, M. Garcia-Osuna, A. Panov, and J. Greenamyre. 2000. Chronic systemic pesticide exposure reproduces features of Parkinson’s disease. Nature Neuroscience 3:12 1301-1306.\u00a0 To read the entire article:\u00a0Betarbet et al. 2000<\/a><\/p>\n Biotech Research Laboratories, Inc. 1982. Analytical studies for the detection of chromosomal aberrations in fruit flies, rats, mice and horse bean.\u00a0 Final Report January 10, 1982, submitted to USFWS, National Fishery Research Laboratory by Biotech Research Laboratories, Inc., Rockville, MD.\u00a0 To read the entire report:\u00a0Biotech Research Laboratories (1982)<\/a><\/p>\n Brusick, D., H. Paulin, D. Jagannath, C. Rabenold, and J. McGowan.\u00a0 1981.\u00a0 Mutagenicity studies on rotenone.\u00a0 Final Report June 24, 1981, submitted to USFWS, National Fishery Research Laboratory by Litton Bionetics, Inc., Kensigton, MD.\u00a0 To read the entire report:\u00a0Brusick (1981)<\/a><\/p>\n Eiseman, J. L., and A. K. Thakur. 1984. General metabolism study for safety evaluation of rotenone using rats.\u00a0 Final Report October 16, 1984 submitted to USFWS, National Fishery Research Laboratory by Hazleton Laboratories, Inc.,Vienna, VA.\u00a0 To read the entire report:\u00a0Eiseman and Thakur (1984)<\/a>.\u00a0 To read the EPA review of the report:\u00a0Eiseman and Thakur (1984) EPA Review<\/a><\/p>\n Ellis, H. V., Unwin, S., Cox, J., Elwood, I. S., Castillo, E. A., Ellis, E. R., Carter, J. 1980.\u00a0 Subchronic oral dosing study for safety evaluation of rotenone using dogs.\u00a0 Final Report December 1980, submitted to USFWS, National Fishery Research Laboratory by Midwest Research Institute, Kansas City, MO.\u00a0 To read the entire report:\u00a0Ellis et al. (1980)<\/a><\/p>\n Finlayson, B., D. Skaar, J. Anderson, L. Demong, D. Duffield, W. horton, J. Steinkjer, C. VanMaaren.\u00a0 2012.\u00a0 Rotenone use in fish management and Parkinson’s disease: another look.\u00a0 Fisheries 37(10) 471-474.\u00a0 To read then entire article:\u00a0\u00a0Finlayson et al. 2012 <\/a><\/p>\n Freudenthal, R. I., A. P. Leber, D. C. Thake and R. L. Baron.\u00a0 1981.\u00a0 Carcinogenic potential of rotenone: subchronic oral and peritoneal administration to rats and chronic dietary administration to Syrian golden hamsters.\u00a0 USEPA Report EPA-600\/1-81-037 and PB81-190936.\u00a0 Office of Research and Development, Health Effects Research Laboratory,\u00a0 Research Triangle Park, NC.\u00a0 To read the entire report:\u00a0Freudentahl et al. (1981)<\/a><\/p>\n Greenman, D. L., W. Allaben, G. Burger, and R. Kodell. 1993. Bioassay for carcinogenicity of rotenone in female Wistar rats. Fundamental and Applied Toxicology 20: 383 \u2013 390.\u00a0 To read the entire article:\u00a0Greenman et al. (1993)<\/a><\/p>\n Hancock, D., and eight coauthors.\u00a0 2008.\u00a0 Pesticide exposure and risk of Parkinson’s disease: a family-based case-control study.\u00a0 BMC Neurology 8(6), 12 pp.\u00a0 To read entire article here:\u00a0Hancock et. al 2008<\/a><\/p>\n Haworth, S. R. 1979. Salmonella\/mammalian \u2013 microsome plate incorporation mutagenesis assay (rotenone).\u00a0 Final Report June 29, 1979 submitted to USFWS, National Fishery Research Laboratory by EG&G Mason Research Institute, Rockville, MD.\u00a0 To read the entire report here:\u00a0Haworth (1979)<\/a><\/p>\n H\u00f6glinger, G.U., W.\u00a0H.\u00a0Oertel and E.\u00a0C.\u00a0Hirsch.\u00a0 2006.\u00a0 The rotenone model of Parkinsonism \u2014 the five years inspection.\u00a0 Journal Neural Transmission Supplement 70: 269-72.<\/p>\n Hollingworth, R.M. 2001. Inhibitors and uncouplers of mitochondrial oxidative phosphorylation. Pages 1169-1263 in R. Krieger, editor. Handbook of Pesticide Toxicology, 2nd <\/sup>Edition, Academic Press, New York.<\/p>\n Jones, D., V. Simmon, K. Mortelmans, A. Mitchell, E. Evans, M. Jotz, E. Riccio, D. Robinson and B. Kirkhart.\u00a0 1984.\u00a0 In vitro and in vivo mutagenicity studies of environmental chemicals [including rotenone]: micronucleus test\u00a0 \u00a0USEPA Report EPA-600\/1-84-003 and PB84-138973.\u00a0 Office of Research and Development, Health Effects Research Laboratory, Research Triangle Park, NC.\u00a0 To read entire report:\u00a0Jones et al. (1984)<\/a><\/p>\n MacKenzie, K. M. 1981. Teratology study with rotenone in mice.\u00a0 Final Report November 24, 1981 submitted to USFWS, National Fishery Research Laboratory by Raltech Scientific Services, Madison, WI.\u00a0 To read entire report here:\u00a0MacKenzie (1981)<\/a><\/p>\n MacKenzie, K. M. 1982. Teratology study with rotenone in rats. Final Report June 17, 1982 submitted to USFWS National Fishery Research Laboratory by\u00a0 Hazleton Raltech, Inc., Madison, WI.\u00a0 To read entire report here:\u00a0MacKenzie (1982)<\/a><\/p>\n MacKenzie, K. M. 1983. Reproduction study for safety evaluation of rotenone using rats.\u00a0 Final Report February 11, 1983 submitted to USFWS National Fishery Research Laboratory by Hazleton Raltech, Inc., Madison, WI.\u00a0 To read entire report here:\u00a0MacKenzie (1983)<\/a><\/p>\n National Toxicology Program.\u00a0 1984. Mouse Lymphoma Protocol (Rotenone).\u00a0 Research Triangle Park, NC.\u00a0 To read entire report here:\u00a0National Toxicology Porogram (1984)<\/a><\/p>\n National Toxicology Program. 1986. Toxicology and carcinogenesis studies of rotenone (CAS No. 83-79-4) in F344\/N rats and B6C3F mice (feed studies). NTP Technical Report Series No. 320. Triangle Park, NC.\u00a0 To read entire report:\u00a0National Toxicology Program 1986_tr320<\/a><\/p>\n Raffaele, K., S. Vulimiri, and T. Bateson. 2011. Benefits and barriers to using epidemiology data in environmental risk assessment. The Open Epidemiology Journal 4:99\u2013105.\u00a0 Read the entire article here:\u00a0 Raffaele et. al 2011<\/a><\/p>\n Rojo, A.I., C. Cavada, M. Rosa de Sagarra, and A. Cuadrado.\u00a0 2007.\u00a0 Chronic inhalation of rotenone or paraquat does not induce Parkinson’s disease symptoms in mice or rats.\u00a0 Experimental Neurology 208(1): 120-126.<\/p>\n Tisdale, M. 1985. Chronic toxicity study of rotenone in rats.\u00a0 Final Report December 30, 1985 submitted to USFWS, National Fishery Research Laboratory by Hazelton Laboratories America, Inc., Madison, WI.\u00a0 To read the entire report here:\u00a0Tisdale (1985)<\/a><\/p>\n USEPA.\u00a0 1985.\u00a0 Review of Eiseman, J. L., and A. K. Thakur. 1984. General metabolism study for safety evaluation of rotenone using rats.\u00a0 To read the entire report:\u00a0Eiseman and Thakur (1984) EPA Review<\/a><\/p>\n